After Brooklyn mob widow Rena Ruggiero hits her 80-year-old neighbor Enzio in the head with an ashtray when he makes an unwanted move on her, she retreats to the Bronx home of her estranged daughter, Adrienne, and her granddaughter, Lucia, only to be turned away at the door. But Lucia's boyfriend Richie has massacred a few members of the Brancaccio crime family for a big payday, and they are going to need to skip town. Rena is along for the ride—as is "Wolfie" Wolfstein, a Golden Age porn star and retired Florida Suncoast grifter. Right behind them, though, is an unhinged enforcer named Crae, and it could be quite a trip.