London, 1943. Across the city, prominent figures in science and the military are bursting into flames. Convinced that the Germans have deployed a new terror weapon, a desperate government turns to the one man who can track down the source of this dreadful menace—Sherlock Holmes. The quest for a solution drives Holmes into an uneasy alliance with the country's most brilliant scientist, Professor James Moriarty. Only Sherlock Holmes knows that behind his respectable façade, Moriarty is the mastermind of a criminal empire.